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If GI symptoms are severe, the solution is slower dose titration (extending intervals between increases from 4 weeks to 68 weeks), eating smaller meals with lower fat content, and potentially adding ginger or vitamin B6 which have anti-nausea effects through different mechanisms

For researchers prioritizing regulatory certainty, real-world safety data, and established protocols, Tirzepatide remains the gold standard in the GLP-1 agonist class as of 2026

doi: 10.1161/circulationaha.107.735795 15 JensterleMRizzoMHaluzkMJaneA

Table 1 demonstrates Functions, Actions, Clinical Applications and Therapeutic Effects of Antioxidant Substances in Periodontal Health